SUL-151 Decreases Airway Neutrophilia as a Prophylactic and Therapeutic Treatment in Mice after Cigarette Smoke Exposure

Chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) is featured by oxidative stress and chronic inflammation. Due to the poor efficacy of standard glucocorticoid therapy, new treatments are required. Here, we investigated whether the novel compound SUL-151 with mitoprotective properties can be used as a prophylactic and therapeutic treatment in a murine CS-induced inflammation model. SUL-151 (4 mg/kg), budesonide (500 μg/kg), or vehicle were administered via oropharyngeal instillation in this prophylactic and therapeutic treatment setting. The number of immune cells was determined in the bronchoalveolar lavage fluid (BALF). Oxidative stress response, mitochondrial adenosine triphosphate (ATP) production, and mitophagy-related proteins were measured in lung homogenates. SUL-151 significantly decreased more than 70% and 50% of CS-induced neutrophils in BALF after prophylactic and therapeutic administration, while budesonide showed no significant reduction in neutrophils. Moreover, SUL-151 prevented the CS-induced decrease in ATP and mitochondrial mtDNA and an increase in putative protein kinase 1 expression in the lung homogenates. The concentration of SUL-151 was significantly correlated with malondialdehyde level and radical scavenging activity in the lungs. SUL-151 inhibited the increased pulmonary inflammation and mitochondrial dysfunction in this CS-induced inflammation model, which implied that SUL-151 might be a promising candidate for COPD treatment.     

统计过程控制在轮胎设计和制造中的应用

结合我国轮胎行业发展现状及其质量提升与成本控制矛盾,以轮胎质量控制为例,使用统计过程控制工具,通过制造过程与公差设计的优化,将设计过程与制造过程进行关联,进而实现轮胎质量与成本的最优平衡,同时结合互联网发展中的新技术应用,得到进一步的突破。     

多功能橡胶助剂HT918在载重子午线轮胎胎面胶中的应用

研究多功能橡胶助剂HT918在载重子午线轮胎胎面胶中的应用。结果表明:在胎面胶中加入多功能橡胶助剂HT918,胶料的t10和t90缩短,交联密度增大,抗硫化返原性提高;硫化胶的定伸应力和拉伸强度增大,拉断伸长率和撕裂强度减小,耐老化性能、耐屈挠性能和耐磨性能提高,压缩生热降低;轮胎的抗湿滑性能和耐久性能提高,滚动阻力降低;多功能橡胶助剂HT918的综合性能等同或优于国外同类产品。     

基于刚柔耦合环模型的轮胎均匀性建模与分析

轮胎在生产制造过程中会不可避免地产生结构、材料、质量分布等不均匀问题。汽车即使在平稳路面上行驶,轮胎的不均匀性也会引起轴力的波动,并且轴力的高阶谐波还可能引发车辆内部的噪声问题。本研究基于刚柔耦合环模型,提出了一个用于分析轮胎几何不均匀导致的动态响应的理论模型。该模型考虑了径向尺寸偏差的影响,得到了不同垂向负荷下轮胎与路面接触压力分布和接地印痕长度,进而分析了轴头纵向力和径向力的波动,并利用试验数据进行了验证。结果表明,建立的模型可以很好地描述轮胎几何不均匀性对其受力的影响,并预测低速时径向尺寸偏差对径向力波动的影响。     

我国轮胎工业40年发展的真实写照与缩影 ——纪念《轮胎工业》创刊40周年

结合《轮胎工业》创刊40年来的报道内容,综述我国轮胎工业40年来的发展历程。我国轮胎生产从最初的使用棉帘线、天然橡胶生产斜交轮胎,通过不断的技术攻关,逐步发展到生产子午线轮胎、无内胎轮胎、扁平化轮胎,进而到航空轮胎、绿色轮胎、安全轮胎、智能轮胎,每一步发展都包含着大量科技创新和自主知识产权。发展民用航空子午线轮胎、新能源汽车轮胎、免充气轮胎等生产技术是“十四五”的发展重点。     

Synthesis and XPS investigation of superdense lithium-graphite intercalation compound, LiC2

The superdense lithium-graphite intercalation compound (GIC),LiC₂, first synthesized by the author was prepared by the original technique in a piston-cylinder high-pressure chamber with internal heater. Cleaved surfaces of this compound, LiC₃, LiC₆ and pristine graphite were studied by the X-ray photoelectron spectroscopy (XPS) technique. It was shown that chemical shifts of carbon do not vary in the range LiC₆ to LiC₂ which suggests that the additional lithium intercalation into LiC₆ gives no significant change in the charge transfer rate per carbon atom. Carbon/lithium atom ratios were obtained for freshly cleaved surfaces and for the surfaces after argon ion bombardment. It was shown that the bombardment results in the surface decomposition of LiC₂-GIC.     

复合变质处理对铸造热锻模具钢力学性能的影响

研究了变质处理对铸造热锻模具钢力学性能的影响。结果表明：在相同热处理条件下，经RE和RE—Nb复合变质处理后，其冲击韧性与变质处理前相比分别提高了9．7和14．5J／cm^2，常温抗拉强度σb分别提高了82和234MPa，高温抗拉强度分别达到了976和994MPa，而硬度变化不大。     

MICROSTRUCTURE OF RAPIDLY SOLIDIFIED TiAl ALLOY POWDER

The rapidly solidified powder of Ti-34Al-2Mn alloy was obtained by means of ultrasonicgas atomisation (USGA) technique.The tupical size of the powder is 27 μm.X-ray diffractionresults show that the powder consists of major α_2-phase and minor γ-phase.Under opticalmicroscope both equiaxed and dendritical microstructure features were observed on RS pow-der sections.After annealing at 900 ℃/for 2 h in vacuum,most of α_2-phase transforms intoγ-phase,resulting in refinement of structure.     

BEHAVIOR OF Mg AND ITS EFFECT ON MECHANICAL PROPERTIES OF CAST Fe_3Al ALLOYS

Proper addition of 0.002 wt-% Mg to cast Fe_3Al alloy may obviously improve the room andhigh temperature tensile properties.Auger spectra show that Mg segregates near grainboundaries as very thin layers.Observation under TEM reveals that a suitable amount of Mgenhances ability of cooperative internal deformation so that the dislocations will ease the con-tinuous slip deformation through grain boundaries.The fracture feature of Fe_3Al alloy is oftransgranular cleavage at room temperature and cracks initiate at grain boundaries.     

硼对快凝Ni3Al组织结构及力学性能的影响

本文通过快凝及加硼合金化的方法改善金属间化合物Ni_3Al的韧性。实验表明:加入0.5-1.4at.-％的硼对Ni_3Al的塑性提高最有利。结构分析表明:在含1.37at.-％硼的Ni_3Al中,硼以Ni_(23)B_6弥散相及晶界偏聚方式存在;当硼量增至2.22at.-％时,硼以粗大的Ni_(23)B_6及NiB_(12)相在晶界处析出。无硼的Ni_3Al晶界为大角度晶界;当硼加至1.37at.-％时,Ni_3Al晶界以位错排列成亚晶界,以小角晶界形式存在。